Skatole

Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream[1][2].

Product Specifications

CAS Number

[83-34-1]

Product Name Alternative

3-Methylindole; 3-Methyl-1H-indole

UNSPSC

12352005

Hazard Statement

H411

Target

Apoptosis; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p38 MAPK

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Skatole.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CNC2=CC=CC=C12

Molecular Formula

C9H9N

Molecular Weight

131.18

Precautions

H411

References & Citations

[1]Kurata K, et al. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Biochem Biophys Res Commun. 2019 Mar 19;510 (4) :649-655.|[2]Zgarbová E, et al. Skatole: A thin red line between its benefits and toxicity. Biochimie. 2023 May;208:1-12.|[3]Li RL, et al. Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca2+-dependent endoplasmic reticulum stress in VSMCs. Int J Biol Sci. 2024 Jan 1;20 (2) :680-700.