Sanggenon G

Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP) . Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation[1].

Product Specifications

CAS Number

[85698-31-3]

UNSPSC

12352005

Target

Caspase; IAP

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sanggenon-g.html

Purity

97.23

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=CC(O)=C([C@H]4C=C(CC/C=C(C)/C)C[C@@H](C5=CC=C(O)C=C5O)[C@@H]4C(C6=CC=C(O)C=C6O)=O)C(O)=C13

Molecular Formula

C40H38O11

Molecular Weight

694.72

References & Citations

[1]Seiter MA, et al. Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP) . FEBS Open Bio. 2014 Jul 5;4:659-71.