Citalopram (hydrobromide)

Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) . Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect[1].

Product Specifications

CAS Number

[59729-32-7]

Product Name Alternative

(±) -Citalopram hydrobromide; Lu 10-171

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; Serotonin Transporter

Type

Reference compound

Related Pathways

Autophagy; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Citalopram-hydrobromide.html

Purity

99.87

Solubility

DMSO : ≥ 38 mg/mL|H2O : 10 mg/mL (ultrasonic)

Smiles

N#CC1=CC2=C(C(C3=CC=C(F)C=C3)(CCCN(C)C)OC2)C=C1.[H]Br

Molecular Formula

C20H22BrFN2O

Molecular Weight

405.30

Precautions

H302

References & Citations

[1]J Hyttel. Citalopram--pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuropsychopharmacol Biol Psychiatry. 1982;6 (3) :277-95.|[2]Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8 (26) :42789-42807.|[3]F Pollier, et al. Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacology. 2000 Jan;22 (1) :64-76.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

ACS Chem Neurosci. 2025 Jun 18;16 (12) :2312-2321.|Eur J Pharmacol. 2018 Dec 15:841:57-66.|J Clin Psychopharmacol. 2021 Sep-Oct;41 (5) :525-533.|Neurochem Int. 2019 Dec;131:104552.|Pharmacol Res Perspect. 2020 Apr;8 (2) :e00575.|Research Square Preprint. 2021 Feb.|Comput Struct Biotechnol J. 2023 Jul 7:21:3490-3502.|Orebro University. 2024.