Favipiravir

Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP) . Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.

Product Specifications

CAS Number

[259793-96-9]

Product Name Alternative

T-705

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335

Target

Bacterial; DNA/RNA Synthesis; Influenza Virus; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/T_705.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 6.25 mg/mL (ultrasonic)

Smiles

O=C(N)C1=NC(F)=CNC1=O

Molecular Formula

C5H4FN3O2

Molecular Weight

157.10

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Furuta Y, et al. Favipiravir (T-705), a novel viral RNA polymerase inhibitor. Antiviral Res. 2013 Nov;100 (2) :446-54.|[2]Rocha-Pereira J, et al. Favipiravir (T-705) inhibits in vitro norovirus replication. Biochem Biophys Res Commun. 2012 Aug 10;424 (4) :777-80.