Valpromide

Valpromide is an amide derivative of Valproic acid (HY-10585) and an orally active epoxide hydrolase inhibitor that can cross the blood-brain barrier. Valpromide has antiepileptic, anticonvulsant, and antipsychotic effects. Valpromide also exhibits antiviral activity and can inhibit the reactivation of the EBV lytic cycle[1][2][3][4].

Product Specifications

CAS Number

[2430-27-5]

UNSPSC

12352211

Hazard Statement

H302

Target

EBV; Epoxide Hydrolase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Valpromide.html

Purity

99.72

Solubility

DMSO : ≥ 50 mg/mL

Smiles

CCCC(CCC)C(N)=O

Molecular Formula

C8H17NO

Molecular Weight

143.23

Precautions

H302

References & Citations

[1]Pacifici GM, et al. Valpromide inhibits human epoxide hydrolase. Br J Clin Pharmacol. 1986 Sep;22 (3) :269-74.|[2]Gorres KL, et al. Valpromide Inhibits Lytic Cycle Reactivation of Epstein-Barr Virus. MBio. 2016 Mar 1;7 (2) :e00113.|[3]Radatz M, et al. Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid. Epilepsy Res. 1998 Mar;30 (1) :41-8.