H4 Receptor antagonist 1
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.
Product Specifications
CAS Number
[848217-00-5]
Product Name Alternative
MK-0869; MK-869; L-754030
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/H4_Receptor_antagonist_1.html
Purity
99.66
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
CN1CCN(C2=C(OC3=CC=C(Cl)C=C34)C4=NC(C)=N2)CC1
Molecular Formula
C16H17ClN4O
Molecular Weight
316.79
References & Citations
[1]Cramp S, et al. Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists. Bioorg Med Chem Lett. 2010 Apr 15;20 (8) :2516-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H4 Receptor
Available Sizes
Curated Selection
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