RO3244794

RO3244794 is a potent and selective IP (prostacyclin) receptor antagonist, with a pKi of 7.7 and 6.9 in human platelet and recombinant IP receptor system, respectively. RO3244794 exhibits analgesic and anti-inflammatory potential[1].

Product Specifications

CAS Number

[361457-01-4]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ro3244794.html

Purity

99.64

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC(C=C1)=CC=C1C[C@H](C(O)=O)NC(OCC2=CC3=CC(C4=CC=C(C=C4)F)=CC=C3O2)=O

Molecular Formula

C25H19F2NO5

Molecular Weight

451.42

References & Citations

[1]Bley KR, et, al. RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol. 2006 Feb;147 (3) :335-45.