BAA473
BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells[1].
Product Specifications
CAS Number
[27240-87-5]
UNSPSC
12352211
Target
Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/baa473.html
Purity
98.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@]([C@@H](C3=O)O)([C@@](CC4)([H])[C@H](C)CCC(OC)=O)C
Molecular Formula
C25H40O5
Molecular Weight
420.58
References & Citations
[1]Alimov I, et al. Bile acid analogues are activators of pyrin inflammasome. J Biol Chem. 2019 Mar 8;294 (10) :3359-3366.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1
Available Sizes
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