N-Acetylmuramic acid

N-acetylmuramic acid is a component of the bacterial cell wall peptidoglycan, essential for maintaining cell shape and integrity[1]. N-acetylmuramic acid inhibits spore germination by inhibiting a coat-associated hexosaminidase and a core enzyme[2]. N-acetylmuramic acid is required by Bacteroides forsythus for proliferation and the maintenance of its cell shape[3]. N-Acetylmuramic acid inhibits the p38 MAPK/NF-κB signaling pathway, and exhibits anti-inflammatory activity. N-Acetylmuramic acid is orally active[4].

Product Specifications

CAS Number

[10597-89-4]

Product Name Alternative

MurNAc; NAMA

UNSPSC

12352200

Hazard Statement

H302, H371

Target

Bacterial; NF-κB; p38 MAPK

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection; MAPK/ERK Pathway; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-acetylmuramic-acid.html

Purity

99.9

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CC(N[C@@H](C=O)[C@@H](O[C@H](C)C(O)=O)[C@H](O)[C@H](O)CO)=O

Molecular Formula

C11H19NO8

Molecular Weight

293.27

Precautions

H302, H371

References & Citations

[1]Herbold DR, Glaser L. Interaction of N-acetylmuramic acid L-alanine amidase with cell wall polymers. J Biol Chem. 1975 Sep 25;250 (18) :7231-8|[2]Brown W, et al. N-acetylmuramic acid inhibits spore germination and germination enzymes. J Basic Microbiol. 1990;30 (2) :67-72|[3]Wyss C. Dependence of proliferation of Bacteroides forsythus on exogenous N-acetylmuramic acid. Infect Immun. 1989 Jun;57 (6) :1757-9|[4]Wu Z, et al. N-acetylmuramic acid triggers anti-inflammatory capacity in LPS-induced RAW 264.7 cells and mice[J]. journal of functional foods, 2015, 13: 108-116.