ZSTK474

ZSTK474 is an ATP-competitive pan-class I PI3K inhibitor with IC50s of 16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.

Product Specifications

CAS Number

[475110-96-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; PI3K

Type

Reference compound

Related Pathways

Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zstk474.html

Purity

99.71

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

FC(C1=NC2=C(N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)C=CC=C2)F

Molecular Formula

C19H21F2N7O2

Molecular Weight

417.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Kong D, et al. ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. Cancer Sci, 2007, 98 (10), 1638-1642.|[2]Wang P, et al. Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury. J Neuroinflammation. 2016 Aug 22;13 (1) :192.|[3]Liu F, et al. Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling. J Exp Clin Cancer Res. 2018 Jun 25;37 (1) :122.