GNE-3511
GNE-3511 is an orally active bioavailable and brain-penetrant dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM. GNE-3511 can cross the blood-brain-barrier and can be used for the research of neurodegenerative diseases[1].
Product Specifications
CAS Number
[1496581-76-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GNE-3511.html
Purity
99.54
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
N#CC1=CC=NC(NC2=NC(N3CC(F)(F)CC3)=CC(C4CCN(C5COC5)CC4)=C2)=C1
Molecular Formula
C23H26F2N6O
Molecular Weight
440.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Patel S et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J Med Chem. 2015 Jan 8;58 (1) :401-18.|[2]Chen Jiang, et al. Neuronal Dual Leucine Zipper Kinase Mediates Inflammatory and Nociceptive Responses in Cyclophosphamide-Induced Cystitis. J Innate Immun
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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