Orexin B, human (TFA)

Orexin B, human (TFA) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.

Product Specifications

Product Name Alternative

Human orexin B (TFA)

UNSPSC

12352209

Target

Orexin Receptor (OX Receptor)

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/orexin-b-human-tfa.html

Purity

97.03

Solubility

H2O : 12.5 mg/mL (ultrasonic)

Smiles

OC(C(F)(F)F)=O.O=C(N1[C@@H](CCC1)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CO)C(NCC(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)=O)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]3N(CCC3)C(CNC([C@H](CO)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O

Molecular Formula

C123H212N44O35S.C2HF3O2

Molecular Weight

3013.36

References & Citations

[1]Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83 (5) :695-7.|[2]Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92 (4) :573-85.