2,6-Dichloropurine
2,6-Dichloropurine is a pharmaceutical intermediate. 2,6-Dichloropurine can be used to synthesize various PDE inhibitors, human A3 adenosine receptor (AR) antagonists, and CDK inhibitors[1][2][3].
Product Specifications
CAS Number
5451-40-1
UNSPSC
12352200
Hazard Statement
H301
Target
Drug Intermediate
Type
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2-6-dichloropurine.html
Purity
99.95
Solubility
DMSO : ≥ 200 mg/mL
Smiles
C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2
Molecular Formula
C5H2Cl2N4
Molecular Weight
189.00
Precautions
H301
References & Citations
[1]Kozai S, et al. Synthesis and biological activity of 9- (2, 6-difluorobenzyl) -9H-purines bearing chlorine. Chemical and pharmaceutical bulletin, 1999, 47 (4) : 574-575.|[2]Jeong LS, et al. Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists. J Med Chem. 2007 Jul 12;50 (14) :3159-62.|[3]Oumata N, et al. Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J Med Chem. 2008 Sep 11;51 (17) :5229-42.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Available Sizes
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