SMCC-DM1
SMCC-DM1 (DM1-SMCC) is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody agent conjugate (ADC) [1].
Product Specifications
CAS Number
1228105-51-8
Product Name Alternative
DM1-SMCC
UNSPSC
12352203
Hazard Statement
H302, H312, H332
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SMCC-DM1.html
Purity
99.23
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(O[C@H]([C@@]1(C)[C@H]([C@@H]([C@@]2([H])OC(N[C@]3(O)C2)=O)C)O1)CC(N(C)C4=CC(C/C(C)=C/C=C/[C@H]3OC)=CC(OC)=C4Cl)=O)[C@@H](N(C(CCSC(C5=O)CC(N5CC6CCC(C(ON7C(CCC7=O)=O)=O)CC6)=O)=O)C)C
Molecular Formula
C51H66ClN5O16S
Molecular Weight
1072.61
Precautions
H302, H312, H332
References & Citations
[1]Shao S, et al. Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG. Bioorg Med Chem Lett. 2018 May 1;28 (8) :1363-1370.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, stored under nitrogen
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Maytansinoids
Available Sizes
Frequently Asked Questions
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