What is the catalog number for LW6?

The catalog number for LW6 is HY-13671.

What sizes are available for LW6?

LW6 is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does LW6 come in?

LW6 is available in 6 different pack sizes.

LW6 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures LW6?

LW6 is manufactured by QuantiMol.

What is the estimated delivery time for LW6?

Estimated delivery time for LW6 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for LW6?

The safety data sheet for LW6 is available here: http://file.medchemexpress.com/batch_PDF/HY-13671/LW6-SDS-MedChemExpress.pdf.

LW6

LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor with an IC50 value of 4.4 μM, and it is also an inhibitor of MDH2. LW6 decreases HIF-1α protein expression without affecting HIF-1β expression.

Product Specifications

CAS Number

934593-90-5

Product Name Alternative

HIF-1α inhibitor; LW8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LW6.html

Purity

98.86

Solubility

DMF : 17.24 mg/mL (ultrasonic) |DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(OC)C1=CC=C(O)C(NC(COC2=CC=C(C3(C4)CC5CC4CC(C5)C3)C=C2)=O)=C1

Molecular Formula

C26H29NO5

Molecular Weight

435.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Naik R, et al. Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors. J Med Chem. 2014 Nov 26;57 (22) :9522-38.|[2]Lee K, et al. LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line. Biochem Pharmacol. 2010 Oct 1;80 (7) :982-9.|[3]Song JG, et al. Discovery of LW6 as a new potent inhibitor of breast cancer resistance protein.|[4]Sato M, et al. LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Mol Med Rep. 2015 Sep;12 (3) :3462-8.