LW6
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor with an IC50 value of 4.4 μM, and it is also an inhibitor of MDH2. LW6 decreases HIF-1α protein expression without affecting HIF-1β expression.
Product Specifications
CAS Number
934593-90-5
Product Name Alternative
HIF-1α inhibitor; LW8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LW6.html
Purity
98.86
Solubility
DMF : 17.24 mg/mL (ultrasonic) |DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(OC)C1=CC=C(O)C(NC(COC2=CC=C(C3(C4)CC5CC4CC(C5)C3)C=C2)=O)=C1
Molecular Formula
C26H29NO5
Molecular Weight
435.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Naik R, et al. Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors. J Med Chem. 2014 Nov 26;57 (22) :9522-38.|[2]Lee K, et al. LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line. Biochem Pharmacol. 2010 Oct 1;80 (7) :982-9.|[3]Song JG, et al. Discovery of LW6 as a new potent inhibitor of breast cancer resistance protein.|[4]Sato M, et al. LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Mol Med Rep. 2015 Sep;12 (3) :3462-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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