NCGC00262650

NCGC00262650 is a potent apical membrane antigen 1-rhoptry neck protein 2 (AMA1-RON2) interaction inhibitor. NCGC00262650 can block entry of merozoites into red blood cells with an IC50 of 9.8 μM[1].

Product Specifications

CAS Number

[344359-25-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ncgc00262650.html

Purity

99.22

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC1=C2C(N(C3CCCC3)C=C2C4=CC=C(OC)C=C4)=NC=N1

Molecular Formula

C18H20N4O

Molecular Weight

308.38

Precautions

H302, H315, H319

References & Citations

[1]Srinivasan P, et, al. Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion. Nat Commun. 2013;4:2261.