Encorafenib-13C, d3
Encorafenib-13C, d3 is the 13C- and deuterium labeled Encorafenib. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM) .
Product Specifications
Product Name Alternative
LGX818-13C, d3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Isotope-Labeled Compounds; Raf
Type
Isotope-Labeled Compounds
Related Pathways
MAPK/ERK Pathway; Others
Field of Research
Cancer
Purity
98.14
Solubility
10 mM in DMSO
Smiles
O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)([13C]([2H])([2H])[2H])=O)=C3F)=N1
Molecular Formula
C21 13CH24D3ClFN7O4S
Molecular Weight
544.02
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Compounds and compositions as protein kinase inhibitors
 . Patent WO 2011025927 A1|[3]Li Z, et al. Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer Lett. 2016 Jan 28;370 (2) :332-44.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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