Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Encorafenib-13C, d3

Encorafenib-13C, d3 is the 13C- and deuterium labeled Encorafenib. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM) .

Product Specifications

Product Name Alternative

LGX818-13C, d3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Isotope-Labeled Compounds; Raf

Type

Isotope-Labeled Compounds

Related Pathways

MAPK/ERK Pathway; Others

Field of Research

Cancer

Purity

98.14

Solubility

10 mM in DMSO

Smiles

O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)([13C]([2H])([2H])[2H])=O)=C3F)=N1

Molecular Formula

C21 13CH24D3ClFN7O4S

Molecular Weight

544.02

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Compounds and compositions as protein kinase inhibitors
 . Patent WO 2011025927 A1|[3]Li Z, et al. Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer Lett. 2016 Jan 28;370 (2) :332-44.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

More Discoveries

Explore Other Products

Browse additional items from our catalog

SuLt4a1 (NM_031641) Rat Tagged Lenti ORF Clone
RR213253L3 10 µg

SuLt4a1 (NM_031641) Rat Tagged Lenti ORF Clone

Sign In for Pricing
View Details
Fibroblast Growth Factor 4 (FGF-4, Heparin Secretory Transforming Protein 1, HSTF-1, HST-1, HST, Transforming Protein KS3, Heparin-binding Growth Factor 4, HBGF-4, HSTF1, KS3) (Biotin) discontinued
F4210-51-Biotin 100 µL

Fibroblast Growth Factor 4 (FGF-4, Heparin Secretory Transforming Protein 1, HSTF-1, HST-1, HST, Transforming Protein KS3, Heparin-binding Growth Factor 4, HBGF-4, HSTF1, KS3) (Biotin) discontinued

Sign In for Pricing
View Details
Phospho-IRE1 (Ser724) Recombinant Antibody, AbBy Fluor™ 594 Conjugated
bsm-61238R-BF594-01 20 µL

Phospho-IRE1 (Ser724) Recombinant Antibody, AbBy Fluor™ 594 Conjugated

Sign In for Pricing
View Details
Phospho-IRE1 (Ser724) Recombinant Antibody, AbBy Fluor™ 594 Conjugated
bsm-61238R-BF594-02 100 µL

Phospho-IRE1 (Ser724) Recombinant Antibody, AbBy Fluor™ 594 Conjugated

Sign In for Pricing
View Details
RGD1564167 3'UTR GFP Stable Cell Line
TU268900 1.0 mL

RGD1564167 3'UTR GFP Stable Cell Line

Sign In for Pricing
View Details
Mouse Cartilage Oligomeric Matrix Protein (Comp) Elisa Kit
EKC41470 96 Tests

Mouse Cartilage Oligomeric Matrix Protein (Comp) Elisa Kit

Sign In for Pricing
View Details