SIC5-6
SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target[1].
Product Specifications
CAS Number
2410846-16-9
UNSPSC
12352005
Target
Mitosis; Separase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sic5-6.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=[S](N1CCC(C2=CNC3=CC=CC=C23)(C4=CNC5=CC=CC=C45)CC1)(C(C=C6)=CC=C6I)=O
Molecular Formula
C27H24IN3O2S
Molecular Weight
581.47
References & Citations
[1]Henschke L, et al. Identification of Bioactive Small Molecule Inhibitors of Separase. ACS Chem Biol. 2019 Oct 18;14 (10) :2155-2159.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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