MC180295
MC180295 ((rel) -MC180295) is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel) -MC180295) has potent anti-tumor effect[1].
Product Specifications
CAS Number
[2237942-08-2]
Product Name Alternative
(rel) -MC180295
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_rel_-MC180295.html
Concentration
10mM
Purity
98.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C(C(C2=CC=CC=C2[N+]([O-])=O)=O)SC(N[C@@H]3[C@H](C4)CC[C@H]4C3)=N1
Molecular Formula
C17H18N4O3S
Molecular Weight
358.41
References & Citations
[1]Zhang H, et al. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Cell. 2018 Nov 15;175 (5) :1244-1258.e26.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK3; CDK4; CDK5; CDK6; CDK7; CDK9
Available Sizes
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