MR24

MR24, a G-5555 derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 induces G1 phase cell cycle arrest. MR24 can be used for cancer research, such as breast, liver and lung cancers[1].

Product Specifications

CAS Number

3056814-89-9

UNSPSC

12352005

Target

Hippo (MST)

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mr24.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=CC(C2=CC(Cl)=C(C=C2)C3=CC4=C(N(C3=O)CCCCN)N=C(N=C4)NC(CO)CO)=N1

Molecular Formula

C26H29ClN6O3

Molecular Weight

509.00

References & Citations

[1]Marcel Rak, et al. Development of Selective Pyrido[2,3-d]pyrimidin-7 (8H) -one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. J. Med. Chem. 2024.