TREM-1 inhibitory peptide GF9

TREM-1 inhibitory peptide GF9 (Human TREM-1 (213-221) ) is a ligand‐independent TREM‐1 inhibitory nonapeptide GF9 that can blunt excessive inflammation caused by rheumatoid arthritis (RA) [1].

Product Specifications

CAS Number

[1289375-12-7]

Product Name Alternative

Human TREM-1 (213-221)

UNSPSC

12352209

Target

TREM receptor

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/trem-1-inhibitory-peptide-gf9.html

Purity

99.41

Solubility

DMSO : 1.92 mg/mL (ultrasonic; adjust pH to 7 with CH3COOH)

Smiles

OC([C@H](CC1=CC=CC=C1)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC(CN)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C49H76N10O12

Molecular Weight

997.19

References & Citations

[1]Zu T Shen, et al. Rationally designed ligand-independent peptide inhibitors of TREM-1 ameliorate collagen-induced arthritis. J Cell Mol Med. 2017 Oct;21 (10) :2524-2534.