MID-1
Product Specifications
Product Name Alternative
MLV-6976; NC-1209,MLV-6976 (hydrochloride); NC-1200 (hydrochloride)
UNSPSC Description
MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake[1].
Target Antigen
Insulin Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mid-1.html
Purity
99.36
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=C(OCC)C=C2
Molecular Weight
293.30
References & Citations
[1]Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115461/MID-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115461/MID-1-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
312608-54-1
Available Sizes
Curated Selection
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