MID-1

MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake[1].

Product Specifications

CAS Number

[312608-54-1]

Product Name Alternative

MLV-6976; NC-1209,MLV-6976 (hydrochloride); NC-1200 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Insulin Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mid-1.html

Purity

99.36

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=C(OCC)C=C2

Molecular Formula

C12H11N3O4S

Molecular Weight

293.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291 (52) :26627-26635.