2-Methoxyidazoxan (monohydrochloride)

2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2) [1][2].

Product Specifications

CAS Number

[109544-45-8]

Product Name Alternative

RX821002 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-methoxyidazoxan-monohydrochloride.html

Purity

98.64

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

COC1(C2=NCCN2)OC3=CC=CC=C3OC1.[H]Cl

Molecular Formula

C12H15ClN2O3

Molecular Weight

270.71

Precautions

H315, H319, H335

References & Citations

[1]Head GA. Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents. Ann N Y Acad Sci. 1995;763:531-540.|[2]Trendelenburg AU, et al. Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1996;353 (3) :245-249.|[3]Sandner G, et al. Effects of caffeine or RX821002 in rats with a neonatal ventral hippocampal lesion. Front Behav Neurosci. 2014;8:15. Published 2014 Jan 28.