TPA 023

TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki of 0.19-0.41 nM.

Product Specifications

CAS Number

[252977-51-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/TPA_023.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC=CC=C1C2=NN=C3C=C(C(C)(C)C)C(OCC4=NC=NN4CC)=NN32

Molecular Formula

C20H22FN7O

Molecular Weight

395.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Atack JR. Subtype-selective GABA (A) receptor modulation yields a novel pharmacological profile: the design and development of TPA023. Adv Pharmacol. 2009;57:137-85|[2]Castner SA, et al. Reversal of ketamine-induced working memory impairments by the GABAAalpha2/3 agonist TPA023. Biol Psychiatry. 2010 May 15;67 (10) :998-1001.