Atipamezole (hydrochloride)
Atipamezole (MPV-1248) hydrochloride is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM[1].
Product Specifications
CAS Number
[104075-48-1]
Product Name Alternative
MPV-1248 hydrochloride
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Atipamezole-hydrochloride.html
Purity
99.97
Solubility
DMSO : ≥ 47 mg/mL|H2O : 75 mg/mL (ultrasonic; warming)
Smiles
CCC1(C2=CN=CN2)CC3=C(C=CC=C3)C1.[H]Cl
Molecular Formula
C14H17ClN2
Molecular Weight
248.75
Precautions
H302, H315, H319, H335
References & Citations
[1]Pertovaara A, et al.Pharmacological properties, central nervous system effects, and potential therapeutic applicationsof atipamezole, a selective alpha2-adrenoceptor antagonist. CNS Drug Rev. 2005 Autumn;11 (3) :273-88.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
α adrenergic receptor
Citation 01
BioRxiv. 2024 November 03.|Protein Cell. 2019 Mar;10 (3) :178-195.|Brain Res. 2020 Sep 15;1743:146949.|Eur J Neurosci. 2021 Apr 27.|Exp Mol Pathol. 2021 Feb;118:104587.|Front Cell Dev Biol. 2021 Mar 11:9:636327.|Research Square Preprint. 2022 May.|Sci Transl Med. 2023 Jan 18;15 (679) :eabq4064.
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