Apigenin-7-glucuronide
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.
Product Specifications
CAS Number
29741-09-1
Product Name Alternative
Apigenin 7-O-glucuronide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MMP
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Apigenin-7-glucuronide.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC(O)=C3C(C=C(C4=CC=C(O)C=C4)OC3=C2)=O
Molecular Formula
C21H18O11
Molecular Weight
446.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83 (11) :901-911.|[2]Deng W, et al. Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomed Pharmacother. 2018 Nov;107:1505-1513.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MMP-13; MMP-3; MMP-8; MMP-9
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