Apigenin-7-glucuronide

Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

Product Specifications

CAS Number

[29741-09-1]

Product Name Alternative

Apigenin 7-O-glucuronide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MMP

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Apigenin-7-glucuronide.html

Concentration

10mM

Purity

99.74

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC(O)=C3C(C=C(C4=CC=C(O)C=C4)OC3=C2)=O

Molecular Formula

C21H18O11

Molecular Weight

446.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83 (11) :901-911.|[2]Deng W, et al. Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomed Pharmacother. 2018 Nov;107:1505-1513.