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RET-IN-3

RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1].

Product Specifications

CAS Number

2414374-53-9

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

RET

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ret-in-3.html

Purity

99.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCCNC1=NC2=C(C3=CC(OCO4)=C4C=C3)C=NN2C=C1

Molecular Formula

C18H21N5O2

Molecular Weight

339.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11 (4) :497-505.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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