RET-IN-3
RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1].
Product Specifications
CAS Number
[2414374-53-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-3.html
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C)CCCNC1=NC2=C(C3=CC(OCO4)=C4C=C3)C=NN2C=C1
Molecular Formula
C18H21N5O2
Molecular Weight
339.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11 (4) :497-505.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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