PBX-7011 (TFA)
Product Specifications
UNSPSC Description
PBX-7011 TFA is a derivative of camptothecin (HY-16560), which inhibits expressions of the cancer related survival genes DDX5, Survivin, Mcl-1 and XIAP in cells FaDu, degrades DDX5 proteins and exhibits anticancer activity[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pbx-7011-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C(F)(F)F.N[C@@H]1C2=C3C(C=C4C(OCO4)=C3CC1)=NC5=C2CN6C5=CC7=C(COC([C@]7(O)CC)=O)C6=O
Molecular Weight
561.46
References & Citations
[1]Jung DY, et al. Camptothecin derivatives that bind to ddx5 protein and prodrugs thereof. WO2023204631A1. 2023-10-26.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160438B/PBX-7011-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160438B/
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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