PBX-7011 (TFA)

PBX-7011 TFA is a derivative of camptothecin (HY-16560), which inhibits expressions of the cancer related survival genes DDX5, Survivin, Mcl-1 and XIAP in cells FaDu, degrades DDX5 proteins and exhibits anticancer activity[1].

Product Specifications

UNSPSC

12352005

Target

Bcl-2 Family; Survivin

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pbx-7011-tfa.html

Purity

99.11

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(O)C(F)(F)F.N[C@@H]1C2=C3C(C=C4C(OCO4)=C3CC1)=NC5=C2CN6C5=CC7=C(COC([C@]7(O)CC)=O)C6=O

Molecular Formula

C26H22F3N3O8

Molecular Weight

561.46

References & Citations

[1]Jung DY, et al. Camptothecin derivatives that bind to ddx5 protein and prodrugs thereof. WO2023204631A1. 2023-10-26.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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