PSMα3
Product Specifications
UNSPSC Description
PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA)[1][2].
Target Antigen
Toll-like Receptor (TLR)
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/psmα3.html
Purity
98.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[C@@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)CC(N)=O)=O)=O)CC(C)C)=O)=O)CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(O)=O)=O)CCCCN)=O)=O)(CC3=CC=CC=C3)NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC5=CC=CC=C5)NC([C@@H](NC([C@H](CCSC)NC=O)=O)CCC(O)=O)=O)=O)C(C)C)=O)C)=O)CCCCN)=O)CC(C)C)=O)=O)CCCCN)=O
Molecular Weight
2635.13
References & Citations
[1]Richardson JR, et, al. Staphylococcus aureus PSM Peptides Modulate Human Monocyte-Derived Dendritic Cells to Prime Regulatory T Cells. Front Immunol. 2018 Nov 13;9:2603.|[2]Tayeb-Fligelman E, et, al. The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril. Science. 2017 Feb 24;355(6327):831-833.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2358/PSMα3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2358/PSMα3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1001405-52-2
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![S6K1 (RPS6KB1) Mouse Monoclonal Antibody [Clone ID: LBI4G4]](https://cdn.genprice.uk/genprice/genprice5.png)
MBS6141010-01 0.1 mL
CCL7 (MCP3, SCYA6, SCYA7, C-C motif Chemokine 7, Monocyte Chemoattractant Protein 3, Monocyte Chemotactic Protein 3, NC28, Small-inducible Cytokine A7, MGC138463, MGC138465) (Biotin)
Ask
View Details MBS6141010-02 5x 0.1 mL
CCL7 (MCP3, SCYA6, SCYA7, C-C motif Chemokine 7, Monocyte Chemoattractant Protein 3, Monocyte Chemotactic Protein 3, NC28, Small-inducible Cytokine A7, MGC138463, MGC138465) (Biotin)
Ask
View Details 
E11A0956-01 48 Well
Bovine Abhydrolase domain containing protein 13 (ABHD13) ELISA Kit
Ask
View Details E11A0956-02 96 Well
Bovine Abhydrolase domain containing protein 13 (ABHD13) ELISA Kit
Ask
View Details