1'-epi Gemcitabine (hydrochloride)

1'-epi Gemcitabine hydrochloride is the isomer of Gemcitabine hydrochloride (HY-B0003), and can be used as an experimental control. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2].

Product Specifications

CAS Number

[122111-05-1]

Product Name Alternative

1'-epi LY 188011 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-epi-gemcitabine-hydrochloride.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O[C@H]1C(F)(F)[C@@H](N2C(N=C(N)C=C2)=O)O[C@@H]1CO.Cl

Molecular Formula

C9H12ClF2N3O4

Molecular Weight

299.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Yip-Schneider MT, et al. Dimethylaminoparthenolide and Gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 17;13:194.|[2]Lou M, et al. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Jun 2;292 (22) :9136-9149.|[3]Gagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer;18 (2) :198-206|[4]Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31 (10) :3171-80