CC260

CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1].

Product Specifications

CAS Number

[2411088-26-9]

UNSPSC

12352005

Target

PI5P4K

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cc260.html

Purity

99.45

Solubility

DMSO : 160 mg/mL (ultrasonic)

Smiles

CN(C1=O)C(C(N(C2CCCC2)[C@@H]1CC3CCCC3)=N4)=CN=C4NC5=CC(Cl)=C(C(Cl)=C5)O

Molecular Formula

C24H29Cl2N5O2

Molecular Weight

490.43

References & Citations

[1]Song Chen, et al. Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc Natl Acad Sci U S A. 2021 May 25;118 (21) :e2002486118.