Wortmannin-Rapamycin Conjugate 1
Wortmannin-Rapamycin Conjugate 1 (compound 7c) is a furan ring-opened derivative of wortmannin-rapamycin conjugate with potent antitumor activities and a fine water solubility. Wortmannin-Rapamycin Conjugate 1 can inhibit the AKT phosphorylation in the tumor and can be used for cancer research[1].
Product Specifications
CAS Number
1067892-47-0
UNSPSC
12352005
Target
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wortmannin-rapamycin-conjugate-1.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12C3=C(C(C(O)=C1/C(C(O[C@@H]2COC)=O)=C\N(C)CCCN(C)C)=O)[C@@]4([H])[C@](C[C@H]3OC(C)=O)([C@H](CC4)OC(CCCCCCC(O[C@H]5[C@@H](C[C@@H](CC5)C[C@H]([C@@]6([H])OC([C@@]7([H])N(CCCC7)C(C([C@@]8(O[C@](CC[C@H]8C)([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@@H]([C@@H](/C(C)=C/[C@H](C(C6)=O)C)O)OC)=O)C)C)OC)O)=O)=O)=O)C)OC)=O)=O)C
Molecular Formula
C88H131N3O23
Molecular Weight
1598.99
References & Citations
[1]Ayral-Kaloustian S, et al. Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) : design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates. J Med Chem. 2010 Jan 14;53 (1) :452-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC681081-500 1x 500 µL
CD45RO (190-2F2.5), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680525-500 1x 500 µL
CD63 (MX-49.129.5), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472853-500 1x 500 µL
CD54 / ICAM-1 (15.2), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details