Antisauvagine-30 (TFA)

Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively[1][2][3][4].

Product Specifications

CAS Number

[9007-83-4]

Product Name Alternative

ASvg-30 (TFA)

UNSPSC

12352211

Target

CRFR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/antisauvagine-30-tfa.html

Purity

98.10

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

[(D-Phe)-HLLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2(TFAsalt)]

Molecular Formula

C163H275N48F3O49S

Molecular Weight

3764.28

References & Citations

[1]Brauns O, et al. Pharmacological and chemical properties of astressin, antisauvagine-30 and alpha-helCRF: significance for behavioral experiments. Neuropharmacology. 2001 Sep;41 (4) :507-16.|[2]Sananbenesi F, et al. Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J Neurosci. 2003 Dec 10;23 (36) :11436-43.|[3]Radulovic J, et al. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J Neurosci. 1999 Jun 15;19 (12) :5016-25.|[4]Klaus Eckart, et al. Action of CRF and its analogs. Current Medicinal Chemistry, 1999, 6, 1035-1053.