Akt1&PKA-IN-2
Akt1&PKA-IN-2 ((R) -29) is an inhibitor of PKB/AKT with cyclin-dependent kinase 2 (CDK2) selectivity. Akt1&PKA-IN-2 inhibits AKT1, PKAa and CDK2a with IC50 values of 0.007 µM, 0.01 µM and 0.69 µM, respectively[1].
Product Specifications
CAS Number
1334108-00-7
UNSPSC
12352005
Target
Akt; CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akt1-pka-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(C=NC=C2)C=C1)N[C@H](C3CNC3)C4=CC(Cl)=C(C=C4)Cl
Molecular Formula
C20H17Cl2N3O
Molecular Weight
386.27
References & Citations
[1]Ashton KS, et al. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2. Bioorg Med Chem Lett. 2011 Sep 15;21 (18) :5191-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1; CDK2
Available Sizes
Frequently Asked Questions
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