Mps1-IN-1 (dihydrochloride)

Mps1-IN-1 dihydrochloride is a potent and ATP-competitive Mps1 kinase inhibitor with an IC50 of 367 nM. Mps1-IN-1 dihydrochloride inhibit Mps1 mitotic kinase activity and abrogates spindle assembly checkpoint (SAC) function. Mps1-IN-1 dihydrochloride decreases the viability of both cancer and ‘normal’ cells[1].

Product Specifications

CAS Number

[1883548-93-3]

UNSPSC

12352005

Target

Mps1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mps1-in-1-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC1CCN(C2=CC=C(NC3=CC(NC4=CC=CC=C4S(=O)(C(C)C)=O)=C5C(NC=C5)=N3)C(OC)=C2)CC1.[H]Cl.[H]Cl

Molecular Formula

C28H35Cl2N5O4S

Molecular Weight

608.58

References & Citations

[1]Nicholas Kwiatkowski, et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May;6 (5) :359-68.