CYM50358
CYM50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25 nM. CYM50358 can be used for the research of influenza infection[1][2].
Product Specifications
CAS Number
1314212-39-9
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cym50358.html
Purity
98.04
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C2=CC(Cl)=CC=C2Cl)O1)NC3=C(C)C=C(CN)C=C3C
Molecular Formula
C20H18Cl2N2O2
Molecular Weight
389.28
Precautions
H301, H311, H331
References & Citations
[1]Guerrero M, et, al. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett. 2011 Jun 15;21 (12) :3632-6.|[2]Onuma T, et, al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
S1PR4
Available Sizes
Frequently Asked Questions
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