VHL-SF2
Product Specifications
UNSPSC Description
VHL-SF2 is a VHL ligand, and can be used for synthesis of PROTACs[1]
Target Antigen
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vhl-sf2.html
Solubility
10 mM in DMSO
Smiles
CC(C)[C@H](C1=CC(C)=NO1)C(N2[C@@H](C[C@H](C2)S(F)(=O)=O)C(N[C@H](C3=CC=C(C4=C(N=CS4)C)C=C3)CC(OC(C)(C)C)=O)=O)=O
Molecular Weight
662.79
References & Citations
[1]Shah RR, et al. Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. J Med Chem. 2024 Mar 28;67(6):4641-4654.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161367/VHL-SF2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161367/
Clinical Information
No Development Reported
CAS Number
3050690-24-6
Curated Selection
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