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Epacadostat (Standard)

Epacadostat (Standard) is the analytical standard of Epacadostat. This product is intended for research and analytical applications. Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM[1].

Product Specifications

Product Name Alternative

INCB 024360 (Standard)

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO) ; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/epacadostat-standard.html

Purity

98.35

Smiles

BrC1=C(F)C=CC(N/C(C2=NON=C2NCCNS(N)(=O)=O)=N\O)=C1

Molecular Formula

C11H13BrFN7O4S

Molecular Weight

438.23

References & Citations

[1]Liu X, et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood. 2010 Apr 29;115 (17) :3520-30.|[2]Koblish HK, et al. Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors. Mol Cancer Ther. 2010 Feb;9 (2) :489-98.|[3]Fu R, et al. LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment. Br J Pharmacol. 2018 Jul;175 (14) :3034-3049.

Shipping Conditions

Blue Ice

Storage Conditions

4°C, sealed storage, away from light and moisture

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-15689R/Epacadostat-Standard-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-15689R/Epacadostat-Standard-SDS-MedChemExpress.pdf

Scientific Category

Reference Standards

CAS Number

[1204669-58-8]

Available Sizes

Curated Selection

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