(Sar1) -Angiotensin II
(Sar1) -Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1) -Angiotensin II binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1) -Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes[1][2][3].
Product Specifications
CAS Number
51833-69-3
UNSPSC
12352209
Target
Angiotensin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sar1-angiotensin-ii.html
Purity
99.84
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC(CNC)=O)CCCNC(N)=N)=O)=O)CC(C=C3)=CC=C3O)=O)=O)CC4=CN=CN4
Molecular Formula
C49H71N13O10
Molecular Weight
1002.17
References & Citations
[1]Matsoukas JM, et, al. Differences in backbone structure between angiotensin II agonists and type I antagonists. J Med Chem. 1995 Nov 10;38 (23) :4660-9.|[2]Aceto JF, et, al. [Sar1]angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. Am J Physiol. 1990 Mar;258 (3 Pt 2) :H806-13.|[3]Millan MA, et, al. Distribution of angiotensin II receptors in the brain of nonhuman primates. Peptides. Mar-Apr 1990;11 (2) :243-53.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
AT1 Receptor
Available Sizes
Frequently Asked Questions
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