MTK458
Product Specifications
UNSPSC Description
MTK458 is an orally active brain penetrant PINK1 activator. MTK458 binds to PINK1 and stabilizes an active heterocomplex, thereby increasing mitophagy. MTK458 can be used for research on Parkinson's disease[1].
Target Antigen
Mitochondrial Metabolism; Mitophagy; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy;Metabolic Enzyme/Protease;Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mtk458.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CC(C(N1)=NC=N2)=C2N[C@H]3C4=CC=CC=C4CCC3
Molecular Weight
332.32
References & Citations
[1]Chin RM, et al. Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528378.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152943/MTK458-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152943/MTK458-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2499962-58-0
Available Sizes
Curated Selection
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