MTK458
MTK458 is an orally active brain penetrant PINK1 activator. MTK458 binds to PINK1 and stabilizes an active heterocomplex, thereby increasing mitophagy. MTK458 can be used for research on Parkinson's disease[1].
Product Specifications
CAS Number
2499962-58-0
Product Name Alternative
EP-0035985
UNSPSC
12352005
Target
Mitochondrial Metabolism; Mitophagy; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mtk458.html
Purity
99.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CC(C(N1)=NC=N2)=C2N[C@H]3C4=CC=CC=C4CCC3
Molecular Formula
C17H15F3N4
Molecular Weight
332.32
References & Citations
[1]Chin RM, et al. Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528378.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PINK1
Available Sizes
Frequently Asked Questions
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