FAS/CD95 Polyclonal Antibody

Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediate apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC) . FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Apt; APO; Tumor necrosis factor receptor superfamily member; Tnfrsf; ALPS1A; APO1; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; CD95; FAS1; FASLG receptor; FASR; FASTM; Tumor necrosis factor receptor superfamily member 6; Apt1; Tnfrsf6; Fas; AI196731 Protein; APO1 Protein; APT1 Protein; CD95 Protein; lpr Protein; TNFR6 Protein; Tnfrsf6 Protein