27-TBDMS-4-Dehydrowithaferin A

27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent[1].

Product Specifications

CAS Number

[1214886-31-3]

UNSPSC

12352005

Hazard Statement

H225-H319

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/27-tbdms-4-dehydrowithaferin-a.html

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@@]3(C(C=CC2=O)=O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@@H]([C@@]6([H])CC(C)=C(C(O6)=O)CO[Si](C)(C)C(C)(C)C)C)C)([H])O3

Molecular Formula

C34H50O6Si

Molecular Weight

582.84

Precautions

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501

References & Citations

[1]Gabriel G Llanos, et al. Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells. Eur J Med Chem. 2012 Aug;54:499-511.