DTRIM24
DTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.
Product Specifications
CAS Number
2170695-14-2
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dTRIM24.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic) |Methanol : 150 mg/mL (ultrasonic)
Smiles
CN(C1=C2C=C(C(NS(C3=CC(C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)=O)=O)=O)=CC=C3)(=O)=O)=C1)OC7=CC=CC(OCCC)=C7)C(N2C)=O
Molecular Formula
C55H68N8O13S2
Molecular Weight
1113.30
Precautions
H315, H319, H320
References & Citations
[1]Gechijian LN, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018 Apr;14 (4) :405-412.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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