EGFR/HER2-IN-16
Product Specifications
UNSPSC Description
EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC50=6.15 nM) and HER-2 (IC50=9.78 nM) with anti-tumor activity. EGFR/HER2-IN-16 can inhibit the migration of SK-BR-3 cells, arrest the cell cycle in the G0/G1 phase, and induce apoptosis. EGFR/HER2-IN-16 exhibits good anti-proliferative activity against tumor cell models and has little damage to healthy cells. EGFR/HER2-IN-16 can be used in breast cancer research[1].
Target Antigen
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-her2-in-16.html
Smiles
O=C(C1=CC=CC(Br)=C1)N2CCN(C3=CC=CC(NC4=C5C=C(C6=CC=CO6)C=CC5=NC=N4)=C3)CC2
Molecular Weight
554.44
References & Citations
[1]Shuang Hao, et al. "Design, synthesis and biological evaluation of novel quinazoline-derived EGFR/HER-2 dual-target inhibitors bearing a heterocyclic-containing tail as potential anti-tumor agents." Bioorganic Chemistry (2024): 107686.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159519/EGFR-HER2-IN-16-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159519/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
RC207564L2V 200 µL
SHFM1 (SEM1) (NM_006304) Human Tagged ORF Clone Lentiviral Particle
Ask
View Details 